News • 13 Aug 2025
Asthma, a chronic respiratory condition, affects millions globally. In 2025, significant strides have been made in understanding and treating asthma, offering patients more effective and personalized care options.
Biologics have revolutionized the management of severe asthma by targeting specific immune pathways involved in inflammation.
Benralizumab (Fasenra): Targets IL-5 receptors to reduce eosinophil levels, effectively controlling eosinophilic asthma. Recent studies have shown its efficacy in reducing exacerbations and improving lung function PMC.
Dupilumab (Dupixent): Inhibits IL-4 and IL-13 signaling, addressing both allergic and eosinophilic asthma. It's been approved for various asthma phenotypes and has demonstrated significant improvements in asthma control Asthma & Allergy Foundation of America.
Rademikibart: A novel biologic targeting IL-4Rα, currently under investigation, shows promise in reducing inflammation and improving asthma control Los Angeles Allergist.
Recent studies have highlighted the benefits of combining medications to enhance asthma control:
Albuterol–Budesonide Combination: A multicenter trial found that adding budesonide (an inhaled steroid) to albuterol significantly reduced severe asthma attacks compared to using albuterol alone VUMC News.
Ultra-Long-Acting Beta-Agonists (LABAs): New formulations of LABAs combined with inhaled corticosteroids offer extended bronchodilation, reducing the frequency of dosing and improving patient adherence.
Artificial Intelligence (AI) is increasingly being integrated into asthma care to enhance monitoring and predict exacerbations:
AI Algorithms: Machine learning models analyze data from wearables and patient records to predict exacerbations, stratify risk, and inform personalized treatment plans PMC.
AI-Powered Stethoscopes: Innovations like AI algorithms in stethoscopes can automatically detect wheezing sounds in real-time, aiding in early detection of asthma exacerbations News Center.
Digital Monitoring Apps: Mobile applications equipped with AI capabilities enable patients to track symptoms, medication usage, and environmental triggers, facilitating timely interventions.
Understanding and mitigating environmental and lifestyle factors are crucial in asthma management:
Air Pollution: Exposure to pollutants like ozone and particulate matter can exacerbate asthma symptoms. Strategies to reduce exposure include using air purifiers and avoiding outdoor activities during high pollution periods.
Indoor Allergens: Dust mites, pet dander, and mold are common indoor allergens. Regular cleaning, using allergen-proof bedding, and maintaining humidity levels can help minimize exposure.
Lifestyle Modifications: Regular physical activity, maintaining a healthy weight, and avoiding smoking can improve overall lung health and reduce asthma symptoms.
Despite advancements, access to modern asthma treatments remains a challenge:
Cost of Biologics: The high cost of biologic therapies can limit access for many patients. Insurance coverage and patient assistance programs are essential to make these treatments more accessible.
Healthcare Infrastructure: In some regions, limited healthcare infrastructure and a shortage of trained healthcare professionals can hinder the effective implementation of advanced asthma management strategies.